Prions in Dentistry

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Prions in dentistry--what are they, should we be concerned, and what can we do?

OBJECTIVE To briefly review the characteristics of prions, the risk of transmission and implications for infection control in dentistry. METHODS The literature on prion disease in the context of dentistry up to March 2005 was reviewed using the PubMed, MEDLINE, Cumulative Index to Nursing & Allied Health Literature, Google Scholar databases and the Web sites of the departments of health of co...

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Prions.

The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transforming bacteria (Avery et al. 1944). Four decades later, the discovery that a protein could mimic viral and bacterial pathogens with respect to the ...

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Prions.

Infectious proteins (prions) are usually self-templating filamentous protein polymers (amyloids). Yeast prions are genes composed of protein and, like the multiple alleles of DNA-based genes, can have an array of "variants," each a distinct self-propagating amyloid conformation. Like the lethal mammalian prions and amyloid diseases, yeast prions may be lethal, or only mildly detrimental, and sh...

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ژورنال

عنوان ژورنال: Dental Journal of Advance Studies

سال: 2013

ISSN: 2321-1482,2349-9869

DOI: 10.1055/s-0038-1670587